Anti-POLQ Polyclonal Antibody - SAlexa Fluor 568
Cat: K112920P - SAlexa Fluor 568
Summary:
| 【Product name】：Anti-POLQ Polyclonal Antibody - SAlexa Fluor 568 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：10721 | 【Swiss Prot】：O75417 |
| 【Species reactivity】：Human,Mouse | |
| 【Tested applications】：WB,IHC | |
| 【Immunogen】：A synthetic peptide of human POLQ | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323).MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323).POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963).
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