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Anti-RFX5 Polyclonal Antibody - SAlexa Fluor 594
Cat: K113005P - SAlexa Fluor 594
Summary:
【Product name】:Anti-RFX5 Polyclonal Antibody - SAlexa Fluor 594 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:5993 【Swiss Prot】:P48382
【Species reactivity】:Human;Mouse
【Tested applications】:ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of human RFX5
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
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