Anti-POLE Polyclonal Antibody
Cat: K113101P
Summary:
| 【Product name】：Anti-POLE Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：5426 | 【Swiss Prot】：Q07864 |
| 【Species reactivity】：Human,Mouse | |
| 【Tested applications】：WB | |
| 【Immunogen】：A synthetic peptide of human POLE | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849).Participates in chromosomal DNA replication (By similarity).Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity).Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity).Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199).Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374).
Verified picture:
Western blot analysis with POLE antibody diluted at 1:2000;Lane: Jurkat,HMC1,HeLa,HEL,A549,MCF7.