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Anti-SIGIRR Polyclonal Antibody - HRP
Cat: K113503P - HRP
Summary:
【Product name】:Anti-SIGIRR Polyclonal Antibody - HRP 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:59307 【Swiss Prot】:Q6IA17
【Observed】:51kDa
【Tested applications】:WB
【Recommended dilution】:WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200
【Immunogen】:A synthetic peptide of human SIGIRR
【Public Immunogen Range】:295-345/410aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
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