Anti-GPNMB Polyclonal Antibody
Cat: K113564P
Summary:
| 【Product name】：Anti-GPNMB Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：10457 | 【Swiss Prot】：Q14956 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human GPNMB | |
| 【Public Immunogen Range】：1-490aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with GPNMB antibody diluted at 1:100.