Anti-PLEKHN1 Polyclonal Antibody
Cat: K113614P
Summary:
| 【Product name】：Anti-PLEKHN1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：84069 | 【Swiss Prot】：Q494U1 |
| 【Species reactivity】：Human;Mouse | |
| 【Tested applications】：IHC | |
| 【Immunogen】：Recombinant protein of human PLEKHN1 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010).Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity).Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylserine (PS) (PubMed:18191643).Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (PubMed:29531808) (By similarity).
Verified picture:
Immunohistochemistry of paraffin-embedded Human testis cancer with PLEKHN1 antibody diluted at 1:100.