Anti-JUNB Polyclonal Antibody - Cy3.5
Cat: K113673P - Cy3.5
Summary:
| 【Product name】：Anti-JUNB Polyclonal Antibody - Cy3.5 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：3726 | 【Swiss Prot】：P17275 |
| 【Species reactivity】：Human;Mouse;Rat | |
| 【Tested applications】：WB | |
| 【Immunogen】：A synthetic peptide of human JUNB | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
JunB is one of the components of the Activator Protein-1 (AP-1) transcription complex that have been implicated in the control ofthe G0/G1 transtion in fibroblasts. AP-1 is a collection of dimers formed by members of the Jun-, Fos-, ATF- and Maf multigene families that bind to specific DNA regulatory elements called AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and cAMP-responsive elements (CREs). JunB binds to the DNA sequence 5'-TGA[CG]TCA-3', and involves in the regulation of gene activity following the primary growth factor response. It also acts either as a tumor suppressor or as an oncogene depending on the cell and physiopathological context.
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