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Anti-CTLA4 Polyclonal Antibody - HRP
Cat: K114583P - HRP
Summary:
【Product name】:Anti-CTLA4 Polyclonal Antibody - HRP 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:1493 【Swiss Prot】:P16410
【Tested applications】:WB
【Recommended dilution】:WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200
【Immunogen】:A synthetic peptide of human CTLA4
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
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