Background:
Na+/H+ antiporter that extrudes Na+ or Li+ in exchange for external protons across the membrane (PubMed:18000046,PubMed:28154142,PubMed:22948142,PubMed:18508966).Contributes to the regulation of intracellular pH,sodium homeostasis,and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity).Involved in sperm motility and fertility (By similarity).It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).