Anti-CISH Polyclonal Antibody - Cy7
Cat: K115045P - Cy7
Summary:
| 【Product name】：Anti-CISH Polyclonal Antibody - Cy7 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1154 | 【Swiss Prot】：Q9NSE2 |
| 【Observed】：27/36kDa | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：Recombinant protein of human CISH | |
| 【Public Immunogen Range】：50-200aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS); also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI); protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2; IL3; GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
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