Background:
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals; cyclins A through H; share a conserved amino acid sequence of about 9 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1; cyclin G2 contains a C-terminal PEST protein destabilization motif; suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq; Jul 28]