Anti-TIPIN Polyclonal Antibody - Cy5
Cat: K115393P - Cy5
Summary:
| 【Product name】：Anti-TIPIN Polyclonal Antibody - Cy5 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54962 | 【Swiss Prot】：Q9BVW5 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human TIPIN | |
| 【Public Immunogen Range】：1-302aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions，stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
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