Thisgeneencodesacell surfacereceptor andtransmembraneprecursor proteinthat iscleavedby secretases to form a number of peptides.Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation while others form the protein basis of the amyloid plaques found in the brainsofpatients with Alzheimer disease.In addition two of the peptidesare antimicrobial peptides having been shown to have bacteriocidal and antifungal activities.Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).Multipletranscriptvariantsencodingseveraldifferent isoformshavebeenfoundfor thisgene.