Anti-CD8a(AF488) Monoclonal Antibody - Biotin
Cat: K011462M - Biotin
Summary:
| 【Product name】：Anti-CD8a(AF488) Monoclonal Antibody - Biotin | |
| 【Isotype】：IgG2a κ | 【Purification】：Affinity purification |
| 【Gene ID】：12525 | 【Swiss Prot】：P01731 |
| 【Tested applications】：WB ELISA IHC ICC | |
| 【Recommended dilution】：WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Spleen cells or thymocyte membranes | |
| 【Public Immunogen Range】：631-805/805aa | |
| 【Storage】：Store at 2-8℃ in dark.Do not freeze. | |
Background:
CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains.It can be present as a homodimer of CD8 or as a heterodimer of CD8 and CD8 (PMID: 3264320;8253791).CD8 is found on most thymocytes.The majority of class I-restricted T cells express mostly the CD8 heterodimer while CD8 homodimers alone have been found on some gut intraepithelial T cells on some T cell receptor (TCR) T cells and on NK cells (PMID: 2111591;1831127;8420975).CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079).During T cell development CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084).
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