Anti-Phospho-AKT(Ser473) Monoclonal Antibody
Cat: K011522M
Summary:
| 【Product name】：Anti-Phospho-AKT(Ser473) Monoclonal Antibody | |
| 【Isotype】：IgG1 | 【Purification】：Affinity purification |
| 【Gene ID】：207 | 【Swiss Prot】：P31749 |
| 【Observed】：Pig;Rabbit;Canine;Chicken;Zebrafish;Duck | |
| 【Recommended dilution】：WB 1:2000-10000. IHC 1:100-400. FCM 1X10^6 cells+0.5ug. | |
| 【Immunogen】：A synthetic peptide of human Phospho-AKT(Ser473) | |
| 【Public Immunogen Range】：1-210aa | |
| 【Storage】：Store at -20℃.Avoid freeze/thaw cycles. | |
Background:
Acts as a regulator of mitochondrial calcium uptake by mediating phosphorylation of MICU1 in the mitochondrial intermembrane space， impairing MICU1 maturation (PubMed:30504268).Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1， thereby inhibiting METTL1 methyltransferase activity (PubMed:15861136).In response to LPAR1 receptor pathway activation， phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11， thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (PubMed:31204173).
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