Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632， PubMed:18695040， PubMed:18826956， PubMed:22526352， PubMed:23136043， PubMed:29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18695040， PubMed:18826956， PubMed:29899501). Also activated by heat， low pH， citrate and phorbol esters (PubMed:16293632， PubMed:18695040， PubMed:18826956， PubMed:20037586， PubMed:21964574， PubMed:25256292). Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311， PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity).