Anti-CBX3 Monoclonal Antibody
Cat: K000012M
Summary:
| 【Product name】：Anti-CBX3 Monoclonal Antibody | 【Source】：Mouse |
| 【Isotype】：IgG1 | 【Purification】：Affinity purification |
| 【Gene ID】：11335 | 【Swiss Prot】：Q13185 |
| 【Tested applications】：ICC,IP,IF,IHC,WB | |
| 【Recommended dilution】：WB 1:500-1000. IHC 1:50-100. IF 1:50-200. IP 1:20. ICC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human CBX3 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Verified picture:
Western blot analysis with CBX3 antibody diluted at 1:1000;Lane: CHO-K1 COS7 C6 3T3 HeLa.
Immunohistochemistry of paraffin-embedded Prostate Cancer with CBX3 antibody diluted at 1:100.
Immunofluorescence analysis of HeLa using CBX3 antibody diluted at 1:100.
Immunoprecipitation analysis of HeLa extracts using CBX3 antibody(IP:1:20;WB:1:1000).Control IgG: Normal Mouse IgG.