Anti-AMACR Monoclonal Antibody
Cat: K000050M
Summary:
| 【Product name】：Anti-AMACR Monoclonal Antibody | 【Source】：Mouse |
| 【Isotype】：IgG1 | 【Purification】：Affinity purification |
| 【Gene ID】：23600 | 【Swiss Prot】：Q9UHK6 |
| 【Tested applications】：WB,IF,ICC | |
| 【Recommended dilution】：WB 1:500-1000. IF 1:50-200. ICC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human AMACR(C-term) | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)-and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.
Verified picture:
Western blot analysis with AMACR antibody diluted at 1:1000;Lane: Rat Liver.
Immunofluorescence analysis of Jurkat using AMACR antibody diluted at 1:100.