Anti-PCNA Monoclonal Antibody - Biotin
Cat: K000119M - Biotin
Summary:
| 【Product name】：Anti-PCNA Monoclonal Antibody - Biotin | 【Source】：Mouse |
| 【Isotype】：IgG2b | |
| 【Gene ID】：5111 | 【Swiss Prot】：P12004 |
| 【Species reactivity】：Mouse,Rat,Human,Hamster,Monkey | |
| 【Tested applications】：WB ELISA IHC ICC | |
| 【Recommended dilution】：WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human PCNA | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta.The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication.In response to DNA damage,this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway.Two transcript variants encoding the same protein have been found for this gene.Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.[provided by RefSeq,Jul 2008]
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