Anti-Cleaved PARP Monoclonal Antibody - SAlexa Fluor 594
Cat: K000215M - SAlexa Fluor 594
Summary:
| 【Product name】：Anti-Cleaved PARP Monoclonal Antibody - SAlexa Fluor 594 | 【Source】：Mouse |
| 【Isotype】：IgG1 | 【Purification】：Saturated ammonium sulfate precipitation |
| 【Gene ID】：142 | 【Swiss Prot】：P09874 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Synthetic Peptide | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.
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