Anti-SIRT1 Polyclonal Antibody
Cat: K000319P
Summary:
| 【Product name】：Anti-SIRT1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：23411 | 【Swiss Prot】：Q96EB6 |
| 【Tested applications】：IF,WB | |
| 【Recommended dilution】：WB 1:500-2000. IF 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human SIRT1 | |
| 【Public Immunogen Range】：201-300aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Verified picture:
Immunofluorescence analysis of NIH/3T3 cells using SIRT1 antibody diluted at 1:100
Western blot analysis with SIRT1 antibody diluted at 1:2000