Anti-SFPQ Polyclonal Antibody - SAlexa Fluor 594
Cat: K000332P - SAlexa Fluor 594
Summary:
| 【Product name】：Anti-SFPQ Polyclonal Antibody - SAlexa Fluor 594 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6421 | 【Swiss Prot】：P23246 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human SFPQ | |
| 【Public Immunogen Range】：578-707aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD.
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