下载
Anti-UPF1 Polyclonal Antibody
Cat: K000348P
Summary:
【Product name】:Anti-UPF1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:5976 【Swiss Prot】:Q92900
【Species reactivity】:Mouse,Rat,Human
【Tested applications】:IP,IF,WB
【Immunogen】:Recombinant protein of human UPF1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
Verified picture:
Immunofluorescence analysis of U-2OS cells using UPF1 antibody diluted at 1:100
Western blot analysis with UPF1 antibody diluted at 1:1000;Lane: HeLa 293T SH-SY5Y K-562 HL-60 Mouse liver.