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Anti-MAPK1 Polyclonal Antibody
Cat: K001612P
Summary:
【Product name】:Anti-MAPK1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:5594 【Swiss Prot】:P28482
【Species reactivity】:Mouse,Rat,Human
【Tested applications】:IF,WB
【Immunogen】:A synthetic peptide of human MAPK1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Verified picture:
Immunofluorescence analysis of A549 cell using MAPK1 antibody. Blue: DAPI for nuclear staining.
Western blot analysis with MAPK1 antibody diluted at 1:1000;Lane: HeLa A549 NIH3T3 C6 Mouse brain Mouse thymus Rat brain.