Anti-TNFRSF1B Polyclonal Antibody - HRP
Cat: K002104P - HRP
Summary:
| 【Product name】：Anti-TNFRSF1B Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：7133 | 【Swiss Prot】：P20333 |
| 【Species reactivity】：Mouse,Rat,Human | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human TNFRSF1B | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
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