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Anti-SMAD2 Polyclonal Antibody
Cat: K002265P
Summary:
【Product name】:Anti-SMAD2 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:4087 【Swiss Prot】:Q15796
【Species reactivity】:Human,Rat,Mouse
【Tested applications】:IHC,WB
【Immunogen】:A synthetic peptide of human SMAD2
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with oth
Verified picture:
Immunohistochemistry of paraffin-embedded prostate(hu) using SMAD2 antibody at dilution of 1:100 (x40 lens).
Western blot analysis with SMAD2 antibody diluted at 1:1000;Lane: HT-1080 C2C12.
Immunohistochemistry of paraffin-embedded human urothelial carcinoma with SMAD2 antibody diluted at 1:75.