Anti-SMAD7 Polyclonal Antibody - Cy3.5
Cat: K002509P - Cy3.5
Summary:
| 【Product name】：Anti-SMAD7 Polyclonal Antibody - Cy3.5 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：4092 | 【Swiss Prot】：O15105 |
| 【Species reactivity】：Rat,Human,Mouse | |
| 【Tested applications】：IF,WB | |
| 【Immunogen】：A synthetic peptide of human SMAD7 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Verified picture: