Anti-OGDH Polyclonal Antibody
Cat: K002573P
Summary:
| 【Product name】：Anti-OGDH Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：4967 | 【Swiss Prot】：Q02218 |
| 【Species reactivity】：Rat,Mouse,Human | |
| 【Tested applications】：IF,IHC,WB | |
| 【Immunogen】：Recombinant protein of human OGDH | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Verified picture:
Immunohistochemistry of paraffin-embedded rat brain tissue using OGDH antibody at dilution of 1:100 (x40 lens).
Western blot analysis with OGDH antibody diluted at 1:1000;Lane: Mouse kidney Mouse heart Mouse brain.
Immunofluorescence analysis of U2OS cells using OGDH antibody diluted at 1:100.