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Anti-CLDN11 Polyclonal Antibody
Cat: K002574P
Summary:
【Product name】:Anti-CLDN11 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:5010 【Swiss Prot】:O75508
【Species reactivity】:Mouse,Rat,Human
【Tested applications】:IHC,WB
【Immunogen】:A synthetic peptide of human CLDN11
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Verified picture:
Western blot analysis with CLDN11 antibody diluted at 1:1000;Lane: NCI-H460 DU145 SW480 Mouse kidney Mouse lung Rat brain Rat kidney Rat lung.