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Anti-HDAC3 Polyclonal Antibody
Cat: K002605P
Summary:
【Product name】:Anti-HDAC3 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:8841 【Swiss Prot】:O15379
【Species reactivity】:Rat,Mouse,Human
【Tested applications】:IF,IHC,WB
【Immunogen】:A synthetic peptide of human HDAC3
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Verified picture:
Immunohistochemistry of paraffin-embedded mouse liver using HDAC3 antibody at dilution of 1:100 (x40 lens).
Western blot analysis with HDAC3 antibody diluted at 1:1000;Lane: HL-60 HeLa Mouse liver.
Immunofluorescence analysis of HeLa cells using HDAC3 antibody diluted at 1:100.