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Anti-COMT Polyclonal Antibody
Cat: K002727P
Summary:
【Product name】:Anti-COMT Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:1312 【Swiss Prot】:P21964
【Species reactivity】:Mouse,Human
【Tested applications】:IP,WB
【Immunogen】:Recombinant protein of human COMT
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Verified picture:
Western blot analysis with COMT antibody diluted at 1:1000;Lane: MCF7 HT-29 THP-1 A431 HepG2 Mouse liver.