Anti-GRK2 Polyclonal Antibody - HRP
Cat: K002909P - HRP
Summary:
| 【Product name】：Anti-GRK2 Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：156 | 【Swiss Prot】：P25098 |
| 【Species reactivity】：Rat,Mouse,Human | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：Recombinant protein of human GRK2 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
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