Anti-AIRE Polyclonal Antibody
Cat: K002971P
Summary:
| 【Product name】：Anti-AIRE Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：326 | 【Swiss Prot】：O43918 |
| 【Species reactivity】：Rat,Mouse,Human | |
| 【Tested applications】：IF,WB | |
| 【Immunogen】：A synthetic peptide of human AIRE | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
Verified picture:
Western blot analysis with AIRE antibody diluted at 1:1000;Lane: MCF7 U-937 HT-29 OVCAR3 SW620 Mouse kidney Mouse liver.
Immunofluorescence analysis of NIH3T3 cells using AIRE antibody diluted at 1:100.