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Anti-SLAMF1 Polyclonal Antibody - SAlexa Fluor 568
Cat: K003170P - SAlexa Fluor 568
Summary:
【Product name】:Anti-SLAMF1 Polyclonal Antibody - SAlexa Fluor 568 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:6504 【Swiss Prot】:Q13291
【Species reactivity】:Mouse,Human
【Tested applications】:WB
【Immunogen】:Recombinant protein of human SLAMF1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Following occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered by a ligand expressed on antigen-presenting cells. SLAM (for signaling lymphocyte-activation molecule, also designated CDw150) is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. SAP (for SLAM-associated protein) contains an SH2 domain and functions to inhibit SH-PTP2 recruitment to the SLAM docking site, an activity induced by Fyn phosphorylation of SLAM. Mutations of the SAP gene may be associated with X-linked lympho-proliferative disease (XLP).
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