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Anti-NR3C1 Polyclonal Antibody
Cat: K003267P
Summary:
【Product name】:Anti-NR3C1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:2908 【Swiss Prot】:P04150
【Species reactivity】:Rat,Human,Mouse
【Tested applications】:IF,IHC,WB
【Immunogen】:Recombinant protein of human NR3C1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Verified picture:
Immunohistochemistry of paraffin-embedded mouse liver using NR3C1 antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded rat spleen with NR3C1 antibody diluted at 1:100.
Immunofluorescence analysis of NIH3T3 cells using NR3C1 antibody diluted at 1:100.