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Anti-PIDD Polyclonal Antibody
Cat: K003850P
Summary:
【Product name】:Anti-PIDD Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:55367 【Swiss Prot】:Q9HB75
【Species reactivity】:Mouse,Rat,Human
【Tested applications】:IF,IHC,WB
【Immunogen】:Recombinant Protein of human PIDD
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.
Verified picture:
Western blot analysis with PIDD antibody diluted at 1:700;Lane: U-87MG 293T K-562 Mouse brain Mouse liver Mouse heart Rat brain.
Immunohistochemistry of paraffin-embedded Rat brain with PIDD antibody diluted at 1:100
Immunofluorescence analysis of HeLa cells using PIDD antibody diluted at 1:100