下载
Anti-HFE2 Polyclonal Antibody - SAlexa Fluor 750
Cat: K003928P - SAlexa Fluor 750
Summary:
【Product name】:Anti-HFE2 Polyclonal Antibody - SAlexa Fluor 750 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:148738 【Swiss Prot】:Q6ZVN8
【Species reactivity】:Rat,Mouse
【Tested applications】:WB
【Immunogen】:Recombinant protein of human HFE2
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Verified picture: