Anti-MLKL Polyclonal Antibody - HRP
Cat: K004074P - HRP
Summary:
| 【Product name】：Anti-MLKL Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：74568 | 【Swiss Prot】：Q9D2Y4 |
| 【Species reactivity】：Mouse,Human | |
| 【Tested applications】：IF,IHC,WB | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：Recombinant protein of mouse MLKL | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.
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