Anti-PC Polyclonal Antibody
Cat: K004420P
Summary:
| 【Product name】：Anti-PC Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：5091 | 【Swiss Prot】：P11498 |
| 【Species reactivity】：Rat,Mouse,Human | |
| 【Tested applications】：IP,IF,WB | |
| 【Immunogen】：Recombinant protein of human PC | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
Verified picture:
Western blot analysis with PC antibody diluted at 1:1000;Lane: HepG2 HeLa MCF7 A549 U-251MG Mouse liver Mouse brain Rat liver Rat brain.
Immunofluorescence analysis of U2OS cell using PC antibody. Blue: DAPI for nuclear staining.