Anti-CCM2 Polyclonal Antibody - SAlexa Fluor 633
Cat: K004601P - SAlexa Fluor 633
Summary:
| 【Product name】：Anti-CCM2 Polyclonal Antibody - SAlexa Fluor 633 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：83605 | 【Swiss Prot】：Q9BSQ5 |
| 【Species reactivity】：Rat,Mouse,Human | |
| 【Tested applications】：IHC,WB | |
| 【Immunogen】：Recombinant protein of human CCM2 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
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