Anti-PNKP Polyclonal Antibody
Cat: K004718P
Summary:
| 【Product name】：Anti-PNKP Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：11284 | 【Swiss Prot】：Q96T60 |
| 【Species reactivity】：Rat,Mouse,Human | |
| 【Tested applications】：IF,IHC,WB | |
| 【Immunogen】：Recombinant protein of human PNKP | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
Verified picture:
Immunohistochemistry of paraffin-embedded rat lung using PNKP antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cell using PNKP antibody. Green��GFP-RNF168 fusion protein expression for DNA damage marker.Blue: DAPI for nuclear staining. RNF168(GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.
Western blot analysis with PNKP antibody diluted at 1:1000;Lane: HL-60 HepG2 Rat liver.
Immunohistochemistry of paraffin-embedded rat kidney with PNKP antibody diluted at 1:100.