Anti-PDE6B Polyclonal Antibody
Cat: K004881P
Summary:
| 【Product name】：Anti-PDE6B Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：5158 | 【Swiss Prot】：P35913 |
| 【Species reactivity】：Human,Rat,Mouse | |
| 【Tested applications】：IHC,WB | |
| 【Immunogen】：Recombinant protein of human PDE6B | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Verified picture:
Western blot analysis with PDE6B antibody diluted at 1:1000;Lane: Mouse liver Mouse pancreas Mouse heart Rat liver.
Immunohistochemistry of paraffin-embedded rat retina with PDE6B antibody diluted at 1:75.