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Anti-MANF Polyclonal Antibody
Cat: K004932P
Summary:
【Product name】:Anti-MANF Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:7873 【Swiss Prot】:P55145
【Species reactivity】:Human,Rat,Mouse
【Tested applications】:IP,IF,IHC,WB
【Immunogen】:Recombinant protein of human MANF
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Verified picture:
Immunofluorescence analysis of U20S cell using MANF antibody. Blue: DAPI for nuclear staining.
Western blot analysis with MANF antibody diluted at 1:1000;Lane: HT-29 HepG2 BxPC-3 Mouse testis Mouse pancreas Rat testis.
Immunohistochemistry of paraffin-embedded human tonsil with MANF antibody diluted at 1:100.
Immunofluorescence analysis of HeLa cells using MANF antibody diluted at 1:100.