Anti-AGR2 Polyclonal Antibody - RBITC
Cat: K004983P - RBITC
Summary:
| 【Product name】：Anti-AGR2 Polyclonal Antibody - RBITC | 【Source】：Rabbit | 【Source】：Rabbit | |
| 【Isotype】：IgG | 【Isotype】：IgG | ||
| 【Gene ID】：10551 | 【Swiss Prot】：O95994 | 【Gene ID】：10551 | 【Swiss Prot】：O95994 |
| 【Species reactivity】：Rat,Mouse,Human | |||
| 【Tested applications】：WB ELISA IHC ICC IF | |||
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |||
| 【Immunogen】：Recombinant protein of human AGR2 | 【Immunogen】：Recombinant protein of human AGR2 | ||
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | ||
Background:
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
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