Anti-LILRB4 Polyclonal Antibody - SAlexa Fluor 660
Cat: K004989P - SAlexa Fluor 660
Summary:
| 【Product name】：Anti-LILRB4 Polyclonal Antibody - SAlexa Fluor 660 | 【Source】：Rabbit | 【Source】：Rabbit | |
| 【Isotype】：IgG | 【Isotype】：IgG | ||
| 【Gene ID】：11006 | 【Swiss Prot】：Q8NHJ6 | 【Gene ID】：11006 | 【Swiss Prot】：Q8NHJ6 |
| 【Species reactivity】：Human Mouse Rat | |||
| 【Tested applications】：IF,IHC,WB | |||
| 【Immunogen】：Recombinant protein of human LILRB4 | 【Immunogen】：Recombinant protein of human LILRB4 | ||
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | ||
Background:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
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