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Anti-ACTL6B Polyclonal Antibody
Cat: K005019P
Summary:
【Product name】:Anti-ACTL6B Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:51412 【Swiss Prot】:O94805
【Species reactivity】:Rat,Mouse,Human
【Tested applications】:IF,IHC,WB
【Immunogen】:Recombinant protein of human ACTL6B
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. Alternative splicing results in multiple transcript variants.
Verified picture:
Western blot analysis with ACTL6B antibody diluted at 1:1000;Lane: HL-60 22Rv1 BT-474 HeLa HepG2 Mouse brain Mouse skeletal muscle.
Immunohistochemistry of paraffin-embedded human kidney using ACTL6B antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis of A549 cell using ACTL6B antibody.