Anti-DPM1 Polyclonal Antibody
Cat: K005443P
Summary:
| 【Product name】：Anti-DPM1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：8813 | 【Swiss Prot】：O60762 |
| 【Species reactivity】：Rat,Mouse,Human | |
| 【Tested applications】：IF,WB | |
| 【Immunogen】：Recombinant protein of human DPM1 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.
Verified picture:
Western blot analysis with DPM1 antibody diluted at 1:1000;Lane: NCI-H460 HeLa SKOV3 Mouse pancreas Mouse liver Mouse kidney Rat liver.
Immunofluorescence analysis of U2OS cells using DPM1 antibody diluted at 1:100.