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Anti-SAFB Polyclonal Antibody
Cat: K005561P
Summary:
【Product name】:Anti-SAFB Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:6294 【Swiss Prot】:Q15424
【Species reactivity】:Rat,Mouse,Human
【Tested applications】:IF,IHC,WB
【Immunogen】:Recombinant fusion protein of human SAFB
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Verified picture:
Western blot analysis with SAFB antibody diluted at 1:1000;Lane: U-87MG DU145 NIH3T3 Mouse brain Mouse lung Rat brain.
Immunohistochemistry of paraffin-embedded human colon with SAFB antibody diluted at 1:100.
Immunofluorescence analysis of U2OS cells using SAFB antibody diluted at 1:100.