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Anti-NEDD4L Polyclonal Antibody
Cat: K005649P
Summary:
【Product name】:Anti-NEDD4L Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:23327 【Swiss Prot】:Q96PU5
【Species reactivity】:Rat,Mouse,Human
【Tested applications】:IF,IHC,WB
【Immunogen】:Recombinant protein of human NEDD4L
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Verified picture:
Western blot analysis with NEDD4L antibody diluted at 1:1000;Lane: BT-474 Mouse brain Rat brain.
Immunohistochemistry of paraffin-embedded rat kidney using NEDD4L antibody at dilution of 1:200 (x40 lens).
Immunofluorescence analysis of L929 cells using NEDD4L antibody diluted at 1:100.