Anti-MDC1 Polyclonal Antibody
Cat: K005781P
Summary:
| 【Product name】：Anti-MDC1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：9656 | 【Swiss Prot】：Q14676 |
| 【Species reactivity】：Human | |
| 【Tested applications】：IF,IHC,WB | |
| 【Immunogen】：Recombinant protein of human MDC1 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Verified picture:
Immunohistochemistry of paraffin-embedded Breast cancer(hu) using MDC1 antibody at dilution of 1:100 (x100 lens,x200 lens).
Western blot analysis with MDC1 antibody diluted at 1:1000;Lane: Jurkat LO2.
Immunohistochemistry of paraffin-embedded human lung cancer with MDC1 antibody diluted at 1:150.
Immunofluorescence analysis of U2OS cells using MDC1 antibody diluted at 1:100.